Born in Elgin, Illinois, Meadows was educated in science, receiving a B.A. in chemistry from Carleton College in 1963, and a Ph.D. in biophysics from Harvard in 1968. After a year-long trip with her husband, Dennis Meadows, from England to Sri Lanka and back, she became, along with him, a research fellow at MIT as a member of a team in the department created by Jay Forrester, the inventor of system dynamics as well as the principle of magnetic data storage for computers. She taught at Dartmouth College for 29 years, beginning in 1972. She died in 2001 from a bacterial infection.